[New research on the stimulation of the pituitary-adrenal axis by the oral administration of a sulfurated terpene.]

Reference:

• Therapy 1959, 14:1044-52

In a previous study (Thérapie. 1958, 13 (3) :527-37), the authors demonstrated histologically on guinea pigs and bioclinical on inpatients, the significant functional stimulation that sulfo-terpene carries on cortico-adrenal stimulation characterized:

• In guinea pigs, for obvious hyperplasia of the fasciculata, a very substantial increase of the lipid load.

• In humans, for a steady and often very important for the elimination of cortico-steroids in urine.

In this new study, which aimed to clarify the mode of action, the authors carried out:

• Histological comparison of adrenal, pituitary and other endocrine glands taken from guinea pigs treated and control guinea pigs.

• Tests Sayers and Simpson performed on Wistar rats.

Here are their conclusions:

• The sulfur-containing terpene (+) acting, not by acting cortico-primary, but by stimulating the secretion of cortico-Trophine pituitary (ACTH).

• The sulfur-containing terpene seems exert any action on the thyroid, gonads, pancreas, adrenal medulla, and tolerance seems excellent.

• (+) Therbinthiol.

You can read the following links for more information:

• http://www.ncbi.nlm.nih.gov/pubmed: reference to publication in the MEDLINE database

• http://www.journal-therapie.org: website of the publisher